The emphasis of Leo Stamatatos’ work is to develop a safe and effective vaccine to combat the spread of HIV and to investigate how HIV infection leads to AIDS.
Research
A major area of interest for Stamatatos' lab is to better understand how neutralizing antibodies against HIV are developed during natural HIV-infection, in a subset of individuals infected with HIV. They are particularly interested in:
- identifying immunological pathways that lead to the development of broadly neutralizing antibodies during natural HIV infection and exploit these pathways for vaccine-related purposes
- understanding how the virus evolves to avoid the action of such antibodies
The Stamatotos group utilizes diverse approaches and iterative methodologies to design and test candidate HIV vaccines
Themes
- HIV envelope structure/function relationship
- B cell immunology in the conext of HIV infection
- HIV evolutionary escape pathways and pathogenesis
- HIV vaccine design
Stamatatos’ research is currently supported by the National Institutes of Health (NIH) and the Bill & Melinda Gates Foundation.
Biography
Education
Ph.D. Biochemistry McGill University, Montreal, Canada
M.S. Synthetic Organic Chemistry University of Paris XI, Paris, France
B.S. Biochemistry University of Orleans, Orleans, France
Professional Experience
- Affiliate Professor, Department of Global Health, University of Washington, 2008 - Present
- Full Professor, Seattle Biomedical Research Institute, 2006 - Present
- Associate Member, Seattle Biomedical Research Institute, 2001 - 2006
- Associate Professor, Department of Pathobiology, University of Washington, 2001 - 2008
- Scientific Advisory Committee Member, American Foundation for AIDS Research, 1999 - 2001
- Staff Investigator, Aaron Diamond AIDS Research Center, 1996 - 2001
- Assistant Professor, Rockefeller University, 1996 - 2001
- Research Scientist, Aaron Diamond AIDS Research Center, 1994 - 1996
- UCSF, Cancer Research Institute, School of Medicine, 1992 - 1994
- UCSF, Cancer Research Institute, School of Medicine, 1990 - 1992
- Teaching Assistant in Biochemistry, McGill University, 1985 - 1988
Select Honors and Awards
- Member, Evaluation Board, Infectious Diseases Faculty, Faculty of 1000 Medicine, 2006 - Present
- Member, NIH Study Section, AIDS Immunology and Pathogenesis, 2004 - 2008
- Member, J. Virology Editorial Board, 2007 - Present
- Member, Virology Editorial Board, 2004 - Present
- AmFAR Scholar, 1995 - 1998
- NIH Training Grant (Molecular Analysis of Tumor Viruses), University of California at San Francisco, 1993 - 1994
- Postdoctoral Fellowship, University of California, Universitywide AIDS Research Program, 1991 - 1993
- Faculty of Medicine Fellowship, McGill University, Montreal, Canada, 1986
- Graduate Scholarship Award, Public Benefit Foundation “Alexandros Onassis”, 1984 - 1985
Staff
Adriana Lippy, research technician II
Andrew McGuire, postdoctoral scientist
Andrew Stuart, research associate
Anita Dreyer, postdoctoral fellow
Brian Oliver, senior scientist
Ericka Sjogren, project manager I
Jolene Glenn, research technician II
Kristen Cohen, graduate student
Matthew Gray, senior scientist
Meaghan Jones, research technician II
Miles Lange, postdoctoral scientist
Noah Sather, principal scientist
Sara Carbonetti, research technician II
